Adipokines influence the inflammatory balance in autoimmunity

Cytokine. 2015 Oct;75(2):272-9. doi: 10.1016/j.cyto.2015.04.004. Epub 2015 Jun 1.


Over the past few decades, our understanding of the role of adipose tissue has changed dramatically. Far from simply being a site of energy storage or a modulator of the endocrine system, adipose tissue has emerged as an important regulator of multiple important processes including inflammation. Adipokines are a diverse family of soluble mediators with a range of specific actions on the immune response. Autoimmune diseases are perpetuated by chronic inflammatory responses but the exact etiology of these diseases remains elusive. While researchers continue to investigate these causes, millions of people continue to suffer from chronic diseases. To this end, an increased interest has developed in the connection between adipose tissue-secreted proteins that influence inflammation and the onset and perpetuation of autoimmunity. This review will focus on recent advances in adipokine research with specific attention on a subset of adipokines that have been associated with autoimmune diseases.

Keywords: Adipokine; Autoimmunity; Inflammation; White adipose tissue.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipokines / immunology*
  • Adiponectin / immunology
  • Adipose Tissue, White / metabolism*
  • Autoimmunity / immunology*
  • Chemokines / immunology
  • Humans
  • Inflammation / immunology*
  • Intercellular Signaling Peptides and Proteins / immunology
  • Leptin / immunology
  • Nicotinamide Phosphoribosyltransferase / immunology
  • Obesity / metabolism
  • Resistin / immunology


  • Adipokines
  • Adiponectin
  • Chemokines
  • Intercellular Signaling Peptides and Proteins
  • Leptin
  • RARRES2 protein, human
  • Resistin
  • Nicotinamide Phosphoribosyltransferase