G protein-coupled odorant receptors: From sequence to structure

Protein Sci. 2015 Sep;24(9):1543-8. doi: 10.1002/pro.2717. Epub 2015 Jun 22.


Odorant receptors (ORs) are the largest subfamily within class A G protein-coupled receptors (GPCRs). No experimental structural data of any OR is available to date and atomic-level insights are likely to be obtained by means of molecular modeling. In this article, we critically align sequences of ORs with those GPCRs for which a structure is available. Here, an alignment consistent with available site-directed mutagenesis data on various ORs is proposed. Using this alignment, the choice of the template is deemed rather minor for identifying residues that constitute the wall of the binding cavity or those involved in G protein recognition.

Keywords: binding cavity; odorant receptor; olfactory; sequence; structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Conserved Sequence
  • Humans
  • Mice
  • Models, Molecular
  • Molecular Sequence Data
  • Mutagenesis, Site-Directed
  • Protein Structure, Tertiary
  • Receptors, G-Protein-Coupled / chemistry*
  • Receptors, G-Protein-Coupled / genetics*
  • Receptors, G-Protein-Coupled / metabolism
  • Receptors, Odorant / chemistry*
  • Receptors, Odorant / genetics*
  • Receptors, Odorant / metabolism
  • Sequence Alignment / methods
  • Structure-Activity Relationship


  • Receptors, G-Protein-Coupled
  • Receptors, Odorant