YAP and TAZ: a nexus for Hippo signaling and beyond

Trends Cell Biol. 2015 Sep;25(9):499-513. doi: 10.1016/j.tcb.2015.05.002. Epub 2015 Jun 2.

Abstract

The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss the function of Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding domain (TAZ), the prime mediators of the Hippo pathway, in stem cell biology and tissue regeneration. We highlight their activities in both the nucleus and the cytoplasm and discuss their role as a signaling nexus and integrator of several other prominent signaling pathways such as the Wnt, G protein-coupled receptor (GPCR), epidermal growth factor (EGF), bone morphogenetic protein (BMP)/transforming growth factor beta (TGFβ), and Notch pathways.

Keywords: Notch; Wnt; extracellular matrix; primary cilia; regeneration; stem cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / physiology*
  • Animals
  • Humans
  • Intestinal Mucosa / metabolism
  • Phosphoproteins / physiology*
  • Protein-Serine-Threonine Kinases / physiology*
  • Signal Transduction
  • Stress, Physiological
  • Transcription Factors / physiology*
  • Transcriptional Activation

Substances

  • Adaptor Proteins, Signal Transducing
  • Phosphoproteins
  • TAZ protein, human
  • Transcription Factors
  • YAP1 (Yes-associated) protein, human
  • Hippo protein, human
  • Protein-Serine-Threonine Kinases