[Synthesis of Racemates and Enantiomers of 3-alkylthalidomide Analogs and Determination of Their Absolute Configuration]

Arch Pharm (Weinheim). 1989 Aug;322(8):499-505. doi: 10.1002/ardp.19893220809.
[Article in German]


The syntheses of the racemates and the enantiomers of the title compounds 7a-7c and of racem. 1,3-dimethyl-thalidomide (8) are reported. The absolute configuration of the optically active products is determined. The hypnotic activities of the analogs of thalidomide 7a - 7c and of the intermediates 6a - 6c are to be tested in animals.

Publication types

  • English Abstract

MeSH terms

  • Chemical Phenomena
  • Chemistry
  • Molecular Conformation
  • Stereoisomerism
  • Thalidomide / analogs & derivatives*
  • Thalidomide / chemical synthesis


  • Thalidomide