Dying mRNA Tells a Story of Its Life

Cell. 2015 Jun 4;161(6):1246-8. doi: 10.1016/j.cell.2015.05.043.


In this issue of Cell, Pelechano et al. report that sequencing of mRNA decay intermediates shows surprisingly tight coupling of a major decay pathway to the movement of the last translating ribosome, revealing stress- and starvation-dependent modulation of translation elongation.

Publication types

  • Comment

MeSH terms

  • Protein Biosynthesis*
  • RNA Stability*
  • Ribosomes / metabolism*
  • Saccharomyces cerevisiae / metabolism*