Tex10: A New Player in the Core Pluripotency Circuitry

Cell Stem Cell. 2015 Jun 4;16(6):572-3. doi: 10.1016/j.stem.2015.04.019.


Revealing how the core pluripotency circuitry is orchestrated to maintain the ground state of embryonic stem cells (ESCs) is fundamental for understanding self-renewal and early lineage specifications. In this issue of Cell Stem Cell, Ding et al. (2015) identify a new Sox2-interacting protein, Tex10, which, together with Tet1 and p300, regulate super-enhancers to sustain pluripotency.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cellular Reprogramming / genetics*
  • Enhancer Elements, Genetic / genetics*
  • Epigenesis, Genetic*
  • Humans
  • Nuclear Proteins / metabolism*
  • Pluripotent Stem Cells / metabolism*


  • Nuclear Proteins