Bringing Blood Stem Cell Phenotype, Genotype, and Function Closer Together

Cell Stem Cell. 2015 Jun 4;16(6):574-5. doi: 10.1016/j.stem.2015.05.001.


Imperfect purity, subtypes, and retrospective functional assays compromise efforts to define the molecular identity of hematopoietic stem cells (HSCs). In this issue of Cell Stem Cell, Wilson et al. (2015) use a single-cell-based bioinformatics-experimental strategy to extract a consensus molecular signature from heterogeneous HSC pools. Their data and strategy provide a powerful resource for stem cell characterization.

Publication types

  • Comment

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / metabolism*
  • Humans
  • Single-Cell Analysis / methods*