Nuclease hypersensitivity of the rat cytochrome P450IA1 gene

Biochem Pharmacol. 1989 Dec 15;38(24):4425-8. doi: 10.1016/0006-2952(89)90652-7.

Abstract

The bovine pancreatic deoxyribonuclease I (DNAase I) hypersensitivity of the rat cytochrome P450IA1 gene was investigated. A nuclease-hypersensitive region was observed at approximately 3.2 to 5.1 kilobase pairs upstream of exon 1 in adult and fetal rat liver. This region did not necessarily correlate with gene expression following 3-methylcholanthrene induction, although it may determine the potential for inducibility of this gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blotting, Southern
  • Cytochrome P-450 Enzyme System / genetics*
  • Deoxyribonuclease I / pharmacology*
  • Female
  • Fetus
  • Gene Expression*
  • Genes / drug effects*
  • Genomic Library
  • Liver / enzymology
  • Male
  • Pregnancy
  • Rats
  • Rats, Inbred Strains

Substances

  • Cytochrome P-450 Enzyme System
  • Deoxyribonuclease I