Functional topography of the human entorhinal cortex

Elife. 2015 Jun 8:4:e06738. doi: 10.7554/eLife.06738.


Despite extensive research on the role of the rodent medial and lateral entorhinal cortex (MEC/LEC) in spatial navigation, memory and related disease, their human homologues remain elusive. Here, we combine high-field functional magnetic resonance imaging at 7 T with novel data-driven and model-based analyses to identify corresponding subregions in humans based on the well-known global connectivity fingerprints in rodents and sensitivity to spatial and non-spatial information. We provide evidence for a functional division primarily along the anteroposterior axis. Localising the human homologue of the rodent MEC and LEC has important implications for translating studies on the hippocampo-entorhinal memory system from rodents to humans.

Keywords: entorhinal cortex; fMRI; human; medial temporal lobe; neuroscience.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Cognition / physiology
  • Connectome
  • Entorhinal Cortex / anatomy & histology*
  • Entorhinal Cortex / physiology*
  • Female
  • Humans
  • Linear Models
  • Magnetic Resonance Imaging / methods*
  • Male
  • Mice
  • Models, Neurological*
  • Spatial Navigation / physiology