The effects of intracranial administration of the dopamine agonist apomorphine on penile reflexes and seminal emission in the rat

Brain Res. 1989 Oct 23;500(1-2):325-32. doi: 10.1016/0006-8993(89)90328-4.

Abstract

Previous studies employing systemic administration of the dopamine agonist apomorphine have shown that the dose response curves for apomorphine's effects on penile reflexes and seminal emission differ, suggesting that experimentally separable populations of dopamine receptors regulate these two responses. The present experiments examined the locations of central nervous system DA receptors mediating genital responses in the restrained, supine rate by injecting apomorphine into the medial preoptic area and the paraventricular nucleus through chronic, indwelling cannulae. Medial preoptic area injections facilitated penile reflexes, but not seminal emission, while paraventricular injections facilitated seminal emission. These results suggest that systemically administered apomorphine may facilitate penile reflexes by acting on the medial preoptic area and may enhance seminal emission by acting on the paraventricular nucleus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Apomorphine / pharmacology*
  • Dopamine / physiology*
  • Ejaculation / drug effects*
  • Male
  • Paraventricular Hypothalamic Nucleus / drug effects
  • Paraventricular Hypothalamic Nucleus / physiology*
  • Penis / drug effects
  • Penis / innervation*
  • Penis / physiology
  • Preoptic Area / drug effects
  • Preoptic Area / physiology*
  • Rats
  • Reflex / drug effects*

Substances

  • Apomorphine
  • Dopamine