Impact of Adverse Events Following Immunization in Viet Nam in 2013 on chronic hepatitis B infection

Vaccine. 2016 Feb 3;34(6):869-73. doi: 10.1016/j.vaccine.2015.05.067. Epub 2015 Jun 6.


Adverse Events Following Immunization in Viet Nam in 2013 led to substantial reductions in hepatitis B vaccination coverage (both the birth dose and the three-dose series). In order to estimate the impact of the reduction in vaccination coverage on hepatitis B transmission and future mortality, a widely-used mathematical model was applied to the data from Viet Nam. Using the model, we estimated the number of chronic infections and deaths that are expected to occur in the birth cohort in 2013 and the number of excessive infections and deaths attributable to the drop in immunization coverage in 2013. An excess of 90,137 chronic infections and 17,456 future deaths were estimated to occur in the 2013 birth cohort due to the drop in vaccination coverage. This analysis highlights the importance of maintaining high vaccination coverage and swiftly responding to reported Adverse Events Following Immunization in order to regain consumer confidence in the hepatitis B vaccine.

Keywords: Adverse events following immunization; Disease burden; Hepatitis B; Vaccination coverage; Viet Nam.

MeSH terms

  • Adult
  • Child
  • Child, Preschool
  • Female
  • Hepatitis B Vaccines / adverse effects*
  • Hepatitis B Vaccines / therapeutic use*
  • Hepatitis B, Chronic / epidemiology*
  • Hepatitis B, Chronic / prevention & control
  • Humans
  • Male
  • Models, Theoretical
  • Vaccination / adverse effects*
  • Vaccination / statistics & numerical data*
  • Vietnam / epidemiology


  • Hepatitis B Vaccines