Sleep Deprivation and Circadian Disruption: Stress, Allostasis, and Allostatic Load

Bruce S McEwen; Ilia N Karatsoreos

doi:10.1016/j.jsmc.2014.11.007

Sleep Deprivation and Circadian Disruption: Stress, Allostasis, and Allostatic Load

Sleep Med Clin. 2015 Mar;10(1):1-10. doi: 10.1016/j.jsmc.2014.11.007.

Authors

Bruce S McEwen¹, Ilia N Karatsoreos²

Affiliations

¹ Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: mcewen@mail.rockefeller.edu.
² Department of Integrative Physiology and Neuroscience, Washington State University, 1815 Ferdinand's Lane, Pullman, WA 99164-6520, USA.

Abstract

Sleep has important homeostatic functions, and circadian rhythms organize physiology and behavior on a daily basis to insure optimal function. Sleep deprivation and circadian disruption can be stressors, enhancers of other stressors that have consequences for the brain and many body systems. Whether the origins of circadian disruption and sleep disruption and deprivation are from anxiety, depression, shift work, long-distance air travel, or a hectic lifestyle, there are consequences that impair brain functions and contribute to the cumulative wear and tear on body systems caused by too much stress and/or inefficient management of the systems that promote adaptation.

Keywords: Allostasis; Allostatic load; Circadian disruption; Glycogen; Hippocampus; Oxidative stress; Pro-inflammatory cytokines; Sleep deprivation.

Publication types

Review

MeSH terms

Allostasis / physiology*
Animals
Circadian Rhythm / physiology*
Humans
Mood Disorders / physiopathology
Sleep Deprivation / physiopathology*
Sleep Deprivation / psychology
Stress, Psychological / physiopathology*

Abstract

Publication types

MeSH terms

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