Anti-plasmin inhibitor. V. Structures of novel dimeric eckols isolated from the brown alga Ecklonia kurome OKAMURA

Chem Pharm Bull (Tokyo). 1989 Sep;37(9):2438-40. doi: 10.1248/cpb.37.2438.

Abstract

6,6'-Bieckol (1), 2-O-(2,4,6-trihydroxyphenyl)-6,6'-bieckol (4), and 8,8'-bieckol (2), bispolyphenols with a dibenzo-1,4-dioxin skeleton, have been isolated as potent anti-plasmin inhibitors from the brown alga Ecklonia kurome OKAMURA. Their structures have been determined to be dimers of eckol linked at the C-6 or C-8 positions, through an aryl-aryl bond on the basis of spectral data. Their inhibitory actions on anti-plasmins (alpha 2-macroglobulin and alpha 2-plasmin inhibitor) and some proteases have been examined.

MeSH terms

  • Animals
  • Antifibrinolytic Agents / antagonists & inhibitors*
  • Chemical Phenomena
  • Chemistry
  • Dioxins / isolation & purification
  • Dioxins / pharmacology*
  • Eukaryota / analysis*
  • Phaeophyceae / analysis*
  • Protease Inhibitors / isolation & purification
  • Protease Inhibitors / pharmacology*

Substances

  • Antifibrinolytic Agents
  • Dioxins
  • Protease Inhibitors
  • 6,6'-bieckol
  • 2-O-(2,4,6-trihydroxyphenyl)-6,6'-bieckol
  • 8,8'-bieckol