Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2015 Jun 5;7(6):4542-54.
doi: 10.3390/nu7064542.

Non-Celiac Gluten Sensitivity Has Narrowed the Spectrum of Irritable Bowel Syndrome: A Double-Blind Randomized Placebo-Controlled Trial

Affiliations
Free PMC article
Randomized Controlled Trial

Non-Celiac Gluten Sensitivity Has Narrowed the Spectrum of Irritable Bowel Syndrome: A Double-Blind Randomized Placebo-Controlled Trial

Bijan Shahbazkhani et al. Nutrients. .
Free PMC article

Abstract

Several studies have shown that a large number of patients who are fulfilling the criteria for irritable bowel syndrome (IBS) are sensitive to gluten. The aim of this study was to evaluate the effect of a gluten-free diet on gastrointestinal symptoms in patients with IBS. In this double-blind randomized, placebo-controlled trial, 148 IBS patients fulfilling the Rome III criteria were enrolled between 2011 and 2013. However, only 72 out of the 148 commenced on a gluten-free diet for up to six weeks and completed the study; clinical symptoms were recorded biweekly using a standard visual analogue scale (VAS). In the second stage after six weeks, patients whose symptoms improved to an acceptable level were randomly divided into two groups; patients either received packages containing powdered gluten (35 cases) or patients received placebo (gluten free powder) (37 cases). Overall, the symptomatic improvement was statistically different in the gluten-containing group compared with placebo group in 9 (25.7%), and 31 (83.8%) patients respectively (p < 0.001). A large number of patients labelled as irritable bowel syndrome are sensitive to gluten. Using the term of IBS can therefore be misleading and may deviate and postpone the application of an effective and well-targeted treatment strategy in gluten sensitive patients.

Keywords: IBS; gluten free diet; non-celiac gluten sensitivity.

Figures

Figure 1
Figure 1
Recruitment pathway and reasons for screen failure and withdrawals.
Figure 2
Figure 2
The difference between gluten and placebo groups in the pattern of symptoms. (A) Satisfaction with stool consistency; (B) Pain; (C) Tiredness; (D) Nausea; (E) Bloating.
Figure 3
Figure 3
Suggesting algorithm.

Similar articles

See all similar articles

Cited by 33 articles

See all "Cited by" articles

References

    1. Thompson W.G., Heaton K.W., Smyth G.T., Smyth C. Irritable bowel syndrome in general practice: Prevalence, characteristics, and referral. Gut. 2000;46:78–82. doi: 10.1136/gut.46.1.78. - DOI - PMC - PubMed
    1. Harvey R.F., Salih S.Y., Read A.E. Organic and functional disorders in 2000 gastroenterology outpatients. Lancet. 1983;1:632–634. doi: 10.1016/S0140-6736(83)91802-0. - DOI - PubMed
    1. Rostami K., Rostami-Nejad M., Al Dulaimi D. Post Gastroenteritis gluten intolerance. Gastroenterol. Hepatol. Bed Bench. 2015;8:66–70. - PMC - PubMed
    1. Gibson P.R. Food intolerance in functional bowel disorders. J. Gastroenterol. Hepatol. 2011;26:128–131. doi: 10.1111/j.1440-1746.2011.06650.x. - DOI - PubMed
    1. Saito Y.A., Locke G.R., Talley N.J., Zinsmeister A.R., Fett S.L., Melton L.J., 3rd A comparison of the Rome and Manning criteria for case identification in epidemiological investigations of irritable bowel syndrome. Am. J. Gastroenterol. 2000;95:2816–2824. doi: 10.1111/j.1572-0241.2000.03192.x. - DOI - PubMed

Publication types

Feedback