Effects of psychological stress on male fertility

Nat Rev Urol. 2015 Jul;12(7):373-82. doi: 10.1038/nrurol.2015.112. Epub 2015 Jun 9.


Psychological stress can be defined as any uncomfortable 'emotional experience' accompanied by predictable biochemical, physiological and behavioural changes or responses. Many clinical studies looking at the effects of psychological stress on male fertility have shown that stress is associated with reduced paternity and abnormal semen parameters. Enough scientific evidence exists to suggest that psychological stress could severely affect spermatogenesis, mainly as a result of varying testosterone secretion. The hypothalamic-pituitary-adrenal axis has a direct inhibitory action on the hypothalamic-pituitary-gonadal (HPG) axis and Leydig cells in the testes. The newly discovered hormone, gonadotropin-inhibitory hormone (GnIH), also has an inhibitory effect on the HPG axis. Inhibition of the HPG axis results in a fall in testosterone levels, which causes changes in Sertoli cells and the blood-testis barrier, leading to the arrest of spermatogenesis. Germ cells also become vulnerable to gonadotoxins and oxidation. However, the extent and severity of the effects of psychological stress on human testes is difficult to study and data mostly come from animal models. Despite this limitation, stress as a causative factor in male infertility cannot be ignored and patients should be made aware of its effects on testicular function and fertility and helped to manage them.

Publication types

  • Review

MeSH terms

  • Humans
  • Hypothalamo-Hypophyseal System / physiopathology
  • Infertility, Male / etiology*
  • Male
  • Pituitary-Adrenal System / physiopathology
  • Spermatogenesis
  • Stress, Psychological / complications*
  • Testis / physiopathology
  • Testosterone / physiology


  • Testosterone