Effects of endocytosis on receptor-mediated signaling

Curr Opin Cell Biol. 2015 Aug;35:137-43. doi: 10.1016/j.ceb.2015.05.005. Epub 2015 Jun 6.


Cellular mechanisms of membrane traffic and signal transduction are deeply interconnected. The present review discusses how membrane trafficking in the endocytic pathway impacts receptor-mediated signaling. Examples of recent progress are highlighted, focusing on the endocytosis-signaling nexus in mammals.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Endocytosis*
  • Endosomes / metabolism
  • Humans
  • Signal Transduction* / physiology