The hollow skull: a sign of brain death in Tc-99m HM-PAO brain scintigraphy

Clin Nucl Med. 1989 Dec;14(12):912-6. doi: 10.1097/00003072-198912000-00012.


The advantage of Tc-99m HM-PAO, a newly introduced compound for brain perfusion imaging, is illustrated in three patients with suspicion of brain death. With Tc-99m HM-PAO, the carotid flow study is not essential, as it is in the Tc-99m pertechnetate carotid angiogram; planar images are equally useful; and there is no need for SPECT images. For the diagnosis of brain death, Tc-99m HM-PAO can be injected in the intensive care unit and planar images can be obtained at a later time using a mobile camera or whenever the patient can be moved to the nuclear medicine department.

MeSH terms

  • Adolescent
  • Adult
  • Brain / diagnostic imaging*
  • Brain Death / diagnostic imaging*
  • Carotid Artery, Internal / diagnostic imaging
  • Cerebrovascular Circulation
  • Humans
  • Male
  • Organotechnetium Compounds*
  • Oximes*
  • Radionuclide Imaging
  • Technetium Tc 99m Exametazime


  • Organotechnetium Compounds
  • Oximes
  • Technetium Tc 99m Exametazime