Molecular epidemiology of an outbreak of hand, foot, and mouth disease associated with subgenotype C4a of enterovirus A71 in Nanchang, China in 2014

J Med Virol. 2015 Dec;87(12):2154-8. doi: 10.1002/jmv.24288. Epub 2015 Jun 25.

Abstract

An outbreak of hand, foot, and mouth disease was reported through hospital-based surveillance in Nanchang, China in 2014. A total of 244 cases were reported, 176 (72.1%) cases were tested positive for enteroviruses by direct reverse transcription-polymerase chain reaction, in which enterovirus A71 (EV-A71), coxsackievirus A16 (CV-A16), and untyped enteroviruses (UEV) accounted for 84.1%, 3.4%, and 12.5%, respectively. In this outbreak, children under 5 years old constituted more than 98% of the positive cases, and the ratio of male to female cases was 2.6 to 1 (P < 0.01). Phylogenetic analysis indicated that the Nanchang EV-A71 strains belonged to subgenotype C4a undergoing continuously evolutionary changes.

Keywords: enterovirus A71; foot; hand; molecular epidemiology; mouth disease; subgenotype C4a.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Distribution
  • Child
  • Child, Preschool
  • China / epidemiology
  • Disease Outbreaks*
  • Enterovirus A, Human / classification*
  • Enterovirus A, Human / genetics*
  • Enterovirus A, Human / isolation & purification
  • Evolution, Molecular
  • Female
  • Genotype*
  • Hand, Foot and Mouth Disease / epidemiology*
  • Hand, Foot and Mouth Disease / virology*
  • Humans
  • Infant
  • Male
  • Molecular Epidemiology
  • RNA, Viral / genetics
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • RNA, Viral