SGLT-2 inhibition and glucagon: Cause for alarm?

Trends Endocrinol Metab. 2015 Jul;26(7):337-8. doi: 10.1016/j.tem.2015.05.011. Epub 2015 Jun 6.


Recent studies raised the alarm that the inhibition of sodium-coupled glucose transporter type-2 in humans increases endogenous glucose production rates by an unclear mechanism. Surprisingly, a potential explanation may be linked directly to the alpha-cell. Is this a mechanistic spoiler or an added benefit?

Keywords: HNF4alpha; SGLT-2 inhibitors; alpha-cell; glucagon; glucose production.

Publication types

  • Comment

MeSH terms

  • Animals
  • Benzhydryl Compounds / chemistry*
  • Female
  • Gene Expression Regulation*
  • Glucagon / metabolism*
  • Glucagon-Secreting Cells / metabolism*
  • Glucosides / chemistry*
  • Humans
  • Male
  • Sodium-Glucose Transporter 2 / metabolism*


  • Benzhydryl Compounds
  • Glucosides
  • Sodium-Glucose Transporter 2
  • Glucagon