Trends in Outcome and Hospitalization Cost among Adult Patients with Acute Ischemic Stroke in the United States

. 2015 May;8(2):19-23.

Trends in Outcome and Hospitalization Cost among Adult Patients with Acute Ischemic Stroke in the United States

Hussam A Yacoub¹, Zaid A Al-Qudah², Hafiz M R Khan³, Khosro Farhad⁴, Andrew Bo-Hua Ji⁵, Nizar Souayah⁶

Affiliations

¹ Center for Advanced Health Care, Lehigh Valley Health Network, Allentown, PA, USA.
² Department of Clinical Neurophysiology, Neuromuscular Track, The Neurological Institute of New York, Columbia University, New York, NY, USA.
³ Department of Epidemiology & Biostatistics, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, FL, USA.
⁴ Coastal Neurology Services Inc., Dover, NH, USA.
⁵ Washington University in St. Louis, St. Louis, MO, USA.
⁶ Neurological Institute of New Jersey, Rutgers, The State University of New Jersey, Newark, NJ, USA.

PMID: 26060524
PMCID: PMC4445344

Trends in Outcome and Hospitalization Cost among Adult Patients with Acute Ischemic Stroke in the United States

Hussam A Yacoub et al. J Vasc Interv Neurol. 2015 May.

. 2015 May;8(2):19-23.

Authors

Hussam A Yacoub¹, Zaid A Al-Qudah², Hafiz M R Khan³, Khosro Farhad⁴, Andrew Bo-Hua Ji⁵, Nizar Souayah⁶

Affiliations

¹ Center for Advanced Health Care, Lehigh Valley Health Network, Allentown, PA, USA.
² Department of Clinical Neurophysiology, Neuromuscular Track, The Neurological Institute of New York, Columbia University, New York, NY, USA.
³ Department of Epidemiology & Biostatistics, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, FL, USA.
⁴ Coastal Neurology Services Inc., Dover, NH, USA.
⁵ Washington University in St. Louis, St. Louis, MO, USA.
⁶ Neurological Institute of New Jersey, Rutgers, The State University of New Jersey, Newark, NJ, USA.

PMID: 26060524
PMCID: PMC4445344

Abstract

Introduction: New treatments for acute ischemic stroke (AIS) have been introduced and are expected to improve patients' overall outcomes. We assessed the impact of new therapeutic strategies on outcome and cost of hospitalization among adult patients with AIS in the United States.

Methods: Patients with AIS admitted in the United States in 1993-1994 and 2006-2007 were listed using the Nationwide Inpatient Survey database. We determined the rates of occurrence, hospitalization outcomes, and mean hospital charges for all patients. We further analyzed these variables in the ventilated and nonventilated patients.

Results: We identified 386,043 patients with AIS admitted in the United States in 1993-1994 and 749,766 patients in 2006-2007. The length of hospitalization was significantly higher in 1993-1994 compared with 2006-2007: 6.9 ± 4.2 days versus 4.66 ± 3 days, respectively. In-hospital mortality rate was 8.9% in 1993-1994 and 5.6% in 2006-2007 (P < 0.0001). There was a significant increase in mean hospital charges in 2006-2007 compared with 1993-1994 ($21,916 ± $14,117 versus $9,646 ± $5,727). The length of hospitalization was significantly shorter in 2006-2007 in nonventilated patients. There was a significant increase in mean hospital charges in 2006-2007 compared with 1993-1994 in both ventilated ($81,528 ± $64,526 versus $25,143 ± $17,172, P<0.0001) and nonventilated patients ($21,085 ± $13,042 versus $10,000 ± $6,300, P<0.0001). The mortality rate was significantly lower in 2006-2007 in both subgroups: 46.5% versus 59.8% in ventilated patients and 4.2% versus 8.2% in nonventilated patients (P < 0.0001).

Conclusion: Our study suggests that new therapeutic strategies have improved outcomes and increased cost of hospitalization among adult patients with AIS in the United States over a period of 13 years. The hospitalization cost was significantly higher in the ventilated and nonventilated patients in 2006-2007, which may reflect the impact of new therapeutic strategies, the availability of more intensive care units and stroke centers, and the lower mortality rate in this time period.

Keywords: acute ischemic stroke; cost; length of stay; mortality; outcome.

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References

1. Zuliani G, Cherubini A, Ranzini M, Ruggiero C, Atti AR, Fellin R. Risk factors for short-term mortality in older subjects with acute ischemic stroke. Gerontology. 2006;52(4):231–6. - PubMed
1. Kunst AE, Amiri M, Janssen F. The decline in stroke mortality: exploration of future trends in 7 Western European countries. Stroke. 2011;42(8):2126–30. - PubMed
1. Gray LJ, Sprigg N, Bath PM, et al. Significant variation in mortality and functional outcome after acute ischaemic stroke between Western countries: data from the tinzaparin in acute ischaemic stroke trial (TAIST) J Neurol Neurosurg Psychiatry. 2006;77(3):327–33. - PMC - PubMed
1. Ovbiagele B, Markovic D, Towfighi A. Recent age- and gender-specific trends in mortality during stroke hospitalization in the United States. Int J Stroke. 2011;6(5):379–87. - PubMed
1. Broderick JP, Ferioli S. Assessing stroke incidence and mortality across the United States. Ann Neurol. 2011;69(4):595–6. - PubMed

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[1] Zuliani G, Cherubini A, Ranzini M, Ruggiero C, Atti AR, Fellin R. Risk factors for short-term mortality in older subjects with acute ischemic stroke. Gerontology. 2006;52(4):231–6. - PubMed

[2] Zuliani G, Cherubini A, Ranzini M, Ruggiero C, Atti AR, Fellin R. Risk factors for short-term mortality in older subjects with acute ischemic stroke. Gerontology. 2006;52(4):231–6. - PubMed

[3] Kunst AE, Amiri M, Janssen F. The decline in stroke mortality: exploration of future trends in 7 Western European countries. Stroke. 2011;42(8):2126–30. - PubMed

[4] Kunst AE, Amiri M, Janssen F. The decline in stroke mortality: exploration of future trends in 7 Western European countries. Stroke. 2011;42(8):2126–30. - PubMed

[5] Gray LJ, Sprigg N, Bath PM, et al. Significant variation in mortality and functional outcome after acute ischaemic stroke between Western countries: data from the tinzaparin in acute ischaemic stroke trial (TAIST) J Neurol Neurosurg Psychiatry. 2006;77(3):327–33. - PMC - PubMed

[6] Gray LJ, Sprigg N, Bath PM, et al. Significant variation in mortality and functional outcome after acute ischaemic stroke between Western countries: data from the tinzaparin in acute ischaemic stroke trial (TAIST) J Neurol Neurosurg Psychiatry. 2006;77(3):327–33. - PMC - PubMed

[7] Ovbiagele B, Markovic D, Towfighi A. Recent age- and gender-specific trends in mortality during stroke hospitalization in the United States. Int J Stroke. 2011;6(5):379–87. - PubMed

[8] Ovbiagele B, Markovic D, Towfighi A. Recent age- and gender-specific trends in mortality during stroke hospitalization in the United States. Int J Stroke. 2011;6(5):379–87. - PubMed

[9] Broderick JP, Ferioli S. Assessing stroke incidence and mortality across the United States. Ann Neurol. 2011;69(4):595–6. - PubMed

[10] Broderick JP, Ferioli S. Assessing stroke incidence and mortality across the United States. Ann Neurol. 2011;69(4):595–6. - PubMed

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Trends in Outcome and Hospitalization Cost among Adult Patients with Acute Ischemic Stroke in the United States

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Trends in Outcome and Hospitalization Cost among Adult Patients with Acute Ischemic Stroke in the United States

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