First report of autochthonous transmission of Zika virus in Brazil

Mem Inst Oswaldo Cruz. 2015 Jun;110(4):569-72. doi: 10.1590/0074-02760150192. Epub 2015 Jun 9.


In the early 2015, several cases of patients presenting symptoms of mild fever, rash, conjunctivitis and arthralgia were reported in the northeastern Brazil. Although all patients lived in a dengue endemic area, molecular and serological diagnosis for dengue resulted negative. Chikungunya virus infection was also discarded. Subsequently, Zika virus (ZIKV) was detected by reverse transcription-polymerase chain reaction from the sera of eight patients and the result was confirmed by DNA sequencing. Phylogenetic analysis suggests that the ZIKV identified belongs to the Asian clade. This is the first report of ZIKV infection in Brazil.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aedes / virology*
  • Aged
  • Animals
  • Brazil / epidemiology
  • Female
  • Humans
  • Insect Vectors / virology*
  • Male
  • Middle Aged
  • Phylogeny
  • Polymerase Chain Reaction
  • RNA, Viral / genetics
  • Sequence Analysis, DNA
  • Young Adult
  • Zika Virus / genetics*
  • Zika Virus / isolation & purification
  • Zika Virus Infection / epidemiology
  • Zika Virus Infection / pathology
  • Zika Virus Infection / transmission*
  • Zika Virus Infection / virology*


  • RNA, Viral