Tissue Blood Flow During Remifentanil Infusion With Carbon Dioxide Loading

Anesth Prog. 2015 Summer;62(2):51-6. doi: 10.2344/0003-3006-62.2.51.


The aim of this study was to investigate the effect of changes in end-tidal carbon dioxide tension (ETCO2) during remifentanil (Remi) infusion on oral tissue blood flow in rabbits. Eight male tracheotomized Japan White rabbits were anesthetized with sevoflurane under mechanical ventilation. The infusion rate of Remi was 0.4 μg/kg/min. Carbon dioxide was added to the inspired gas to change the inspired CO2 tension to prevent changes in the ventilating condition. Observed variables were systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), common carotid artery blood flow (CCBF), tongue mucosal blood flow (TBF), mandibular bone marrow tissue blood flow (BBF), masseter muscle tissue blood flow (MBF), upper alveolar tissue blood flow (UBF), and lower alveolar tissue blood flow (LBF). The CCBF, TBF, BBF, UBF, and LBF values were increased, while MBF was decreased, under hypercapnia, and vice versa. The BBF, UBF, and LBF values were increased, while the MBF value was decreased, under hypercapnia during Remi infusion, and vice versa. The BBF, MBF, UBF, and LBF values, but not the CCBF and TBF values, changed along with ETCO2 changes during Remi infusion.

Keywords: End-tidal carbon dioxide; Hypercapnia; Hypocapnia; Oral tissue blood flow; Remifentanil.

MeSH terms

  • Alveolar Process / blood supply
  • Anesthetics, Intravenous / administration & dosage*
  • Animals
  • Arterial Pressure / drug effects
  • Blood Pressure / drug effects
  • Bone Marrow / blood supply
  • Capnography / methods
  • Carbon Dioxide / administration & dosage
  • Carotid Artery, Common / drug effects
  • Heart Rate / drug effects
  • Hypercapnia / physiopathology*
  • Male
  • Mandible / blood supply
  • Masseter Muscle / blood supply
  • Mouth / blood supply*
  • Piperidines / administration & dosage*
  • Rabbits
  • Regional Blood Flow / drug effects
  • Remifentanil
  • Respiration, Artificial / methods
  • Tongue / blood supply
  • Tracheostomy / methods


  • Anesthetics, Intravenous
  • Piperidines
  • Carbon Dioxide
  • Remifentanil