The serologic decoy receptor 3 (DcR3) levels are associated with slower disease progression in HIV-1/AIDS patients

Yu-Ting Lin; Chia-Hung Yen; Heng-Li Chen; Yi-Jen Liao; I-Feng Lin; Marcelo Chen; Yu-Ching Lan; Shao-Yuan Chuang; Shie-Liang Hsieh; Yi-Ming Arthur Chen

doi:10.1016/j.jfma.2013.01.007

The serologic decoy receptor 3 (DcR3) levels are associated with slower disease progression in HIV-1/AIDS patients

J Formos Med Assoc. 2015 Jun;114(6):498-503. doi: 10.1016/j.jfma.2013.01.007. Epub 2013 Mar 13.

Authors

Affiliations

¹ AIDS Prevention and Research Centre, National Yang-Ming University, Taipei 11221, Taiwan.
² Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
³ AIDS Prevention and Research Centre, National Yang-Ming University, Taipei 11221, Taiwan; School of Medical Laboratory Science and Biotechnology, Taipei Medical University, Taipei 11031, Taiwan.
⁴ Institute of Public Health, National Yang-Ming University, Taipei 11221, Taiwan.
⁵ AIDS Prevention and Research Centre, National Yang-Ming University, Taipei 11221, Taiwan; Department of Urology, Mackay Memorial Hospital, Taipei 10449, Taiwan; School of Medicine, Mackay Medical College, New Taipei City 25245, Taiwan.
⁶ AIDS Prevention and Research Centre, National Yang-Ming University, Taipei 11221, Taiwan; Department of Health Risk Management, China Medical University, Taichung 40402, Taiwan.
⁷ Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 35053, Taiwan.
⁸ Institute of Clinical Medicine, National Yang-Ming University, Taipei 11221, Taiwan; Department and Institute of Microbiology and Immunology, National Yang-Ming University, Taipei 11221, Taiwan; Infection and Immunity Research Centre, National Yang-Ming University, Taipei 11221, Taiwan; Immunology Centre, Taipei Veterans General Hospital, Taipei 11221, Taiwan.
⁹ AIDS Prevention and Research Centre, National Yang-Ming University, Taipei 11221, Taiwan; Department of Microbiology, School of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Electronic address: arthur@ym.edu.tw.

PMID: 26062966
DOI: 10.1016/j.jfma.2013.01.007

Abstract

Background/purpose: The decoy receptor 3 (DcR3) is a member of the tumor necrosis factor receptor (TNFR) super-family. It counteracts the biological effects of Fas ligands and inhibits apoptosis. The goals of this study were to understand the associations between serologic DcR3 (sDcR3) levels and different human immunodeficiency virus type 1 (HIV-1) subtypes, as well as the AIDS disease progression.

Methods: Serum samples from 61 HIV/AIDS patients, who had been followed up every 6 months for 3 years, were collected. sDcR3 levels were quantified using an enzyme immunoassay (EIA).

Results: The sDcR3 levels in patients with HIV-1 subtype B were significantly higher than those in patients infected with subtype CRF01_AE (p < 0.001). In addition, multivariable linear mixed model analysis demonstrated that HIV-1 subtype B and slow disease progression were associated with higher levels of sDcR3, adjusting for potential predictors (p = 0.0008 and 0.0455, respectively).

Conclusion: HIV-1-infected cells may gain a survival advantage by activating DcR3, which prevents infected cell detection by the host immune system. These data indicate that the sDcR3 level is a biomarker for AIDS disease progression.

Keywords: HIV/AIDS; decoy receptor 3 (DcR3); disease progression; subtype.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acquired Immunodeficiency Syndrome / blood*
Adult
Apoptosis*
Biomarkers
Disease Progression
Fas Ligand Protein / metabolism*
Female
HIV-1 / classification
Humans
Linear Models
Male
Middle Aged
Receptors, Tumor Necrosis Factor, Member 6b / blood*
Taiwan
Young Adult

Substances

Biomarkers
FASLG protein, human
Fas Ligand Protein
Receptors, Tumor Necrosis Factor, Member 6b
TNFRSF6B protein, human