Fosfomycin for Treatment of Prostatitis: New Tricks for Old Dogs

M Lindsay Grayson; Nenad Macesic; Janine Trevillyan; Andrew G Ellis; Phillip T Zeglinski; Nicholas H Hewitt; Bradley J Gardiner; Albert G Frauman

doi:10.1093/cid/civ436

Fosfomycin for Treatment of Prostatitis: New Tricks for Old Dogs

Clin Infect Dis. 2015 Oct 1;61(7):1141-3. doi: 10.1093/cid/civ436. Epub 2015 Jun 10.

Authors

M Lindsay Grayson¹, Nenad Macesic², Janine Trevillyan³, Andrew G Ellis⁴, Phillip T Zeglinski⁵, Nicholas H Hewitt², Bradley J Gardiner², Albert G Frauman⁴

Affiliations

¹ Department of Infectious Diseases, Austin Health Department of Medicine, University of Melbourne.
² Department of Infectious Diseases, Austin Health.
³ Department of Infectious Diseases, Austin Health Department of Infectious Diseases, Alfred Health.
⁴ Department of Medicine, University of Melbourne Department of Clinical Pharmacology, Austin Health, Melbourne, Australia.
⁵ Department of Medicine, University of Melbourne.

PMID: 26063723
DOI: 10.1093/cid/civ436

Abstract

Treatment options for prostatitis caused by multidrug-resistant gram-negative bacilli are limited. We report two cases cured with oral fosfomycin and provide a pharmacokinetic analysis of fosfomycin predose concentrations during treatment.

Keywords: fosfomycin; microbial drug resistance; pharmacology; prostatitis.

Publication types

Case Reports

MeSH terms

Aged
Aged, 80 and over
Anti-Bacterial Agents / administration & dosage
Anti-Bacterial Agents / blood
Anti-Bacterial Agents / pharmacokinetics
Anti-Bacterial Agents / therapeutic use*
Drug Resistance, Multiple, Bacterial
Fosfomycin / administration & dosage
Fosfomycin / blood
Fosfomycin / pharmacokinetics
Fosfomycin / therapeutic use*
Humans
Male
Prostatitis / drug therapy*
Urinary Tract Infections / drug therapy*

Substances

Anti-Bacterial Agents
Fosfomycin