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Review
, 2015, 723954

Assessing of Celiac Disease and Nonceliac Gluten Sensitivity

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Review

Assessing of Celiac Disease and Nonceliac Gluten Sensitivity

N Ontiveros et al. Gastroenterol Res Pract.

Abstract

The publication of papers on the topic of gluten related disorders has substantially increased over the last few years. This has motivated healthcare professionals to pay attention not only to celiac disease and wheat allergy but also to a condition termed nonceliac gluten sensitivity (NCGS). Until now this condition has been diagnosed clinically on the basis of exclusion criteria and clinical response to gluten withdrawal. In addition, recent research in this field has shown that other food components distinct from gluten are implicated in NCGS cases, thereby changing our general understanding of NCGS diagnosis in either individuals on gluten containing diets or those already following a gluten-free diet with no proper diagnostic work-up of celiac disease. With this in mind, the assessment of NCGS will require extensive knowledge of celiac disease manifestations and the laboratory tests commonly performed during diagnosis of celiac disease.

Figures

Figure 1
Figure 1
Proposed algorithm for CD diagnosis in asymptomatic individuals with positive CD-specific serology. GE: gastrointestinal endoscopy, GFD: gluten-free diet, and F/u: follow-up.
Figure 2
Figure 2
Proposed algorithm for CD diagnosis in patients already following gluten-free diet. GE: gastrointestinal endoscopy, GC: gluten challenge, GFD: gluten-free diet, and F/u: follow-up.

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References

    1. Biesiekierski J. R., Peters S. L., Newnham E. D., Rosella O., Muir J. G., Gibson P. R. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology. 2013;145(2):320–328. doi: 10.1053/j.gastro.2013.04.051. - DOI - PubMed
    1. Peters S. L., Biesiekierski J. R., Yelland G. W., Muir J. G., Gibson P. R. Randomised clinical trial: gluten may cause depression in subjects with non-coeliac gluten sensitivity—an exploratory clinical study. Alimentary Pharmacology and Therapeutics. 2014;39(10):1104–1112. doi: 10.1111/apt.12730. - DOI - PubMed
    1. Junker Y., Zeissig S., Kim S.-J., et al. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. Journal of Experimental Medicine. 2012;209(13):2395–2408. doi: 10.1084/jem.20102660. - DOI - PMC - PubMed
    1. Genuis S. J., Lobo R. A. Gluten sensitivity presenting as a neuropsychiatric disorder. Gastroenterology Research and Practice. 2014;2014:6. doi: 10.1155/2014/293206.293206 - DOI - PMC - PubMed
    1. Volta U., Tovoli F., Cicola R., et al. Serological tests in gluten sensitivity (nonceliac gluten intolerance) Journal of Clinical Gastroenterology. 2012;46(8):680–685. doi: 10.1097/mcg.0b013e3182372541. - DOI - PubMed

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