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, 2015, 723954

Assessing of Celiac Disease and Nonceliac Gluten Sensitivity


Assessing of Celiac Disease and Nonceliac Gluten Sensitivity

N Ontiveros et al. Gastroenterol Res Pract.


The publication of papers on the topic of gluten related disorders has substantially increased over the last few years. This has motivated healthcare professionals to pay attention not only to celiac disease and wheat allergy but also to a condition termed nonceliac gluten sensitivity (NCGS). Until now this condition has been diagnosed clinically on the basis of exclusion criteria and clinical response to gluten withdrawal. In addition, recent research in this field has shown that other food components distinct from gluten are implicated in NCGS cases, thereby changing our general understanding of NCGS diagnosis in either individuals on gluten containing diets or those already following a gluten-free diet with no proper diagnostic work-up of celiac disease. With this in mind, the assessment of NCGS will require extensive knowledge of celiac disease manifestations and the laboratory tests commonly performed during diagnosis of celiac disease.


Figure 1
Figure 1
Proposed algorithm for CD diagnosis in asymptomatic individuals with positive CD-specific serology. GE: gastrointestinal endoscopy, GFD: gluten-free diet, and F/u: follow-up.
Figure 2
Figure 2
Proposed algorithm for CD diagnosis in patients already following gluten-free diet. GE: gastrointestinal endoscopy, GC: gluten challenge, GFD: gluten-free diet, and F/u: follow-up.

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