Prevalence and Prognosis of Pseudoexfoliation Glaucoma in Western India

Asia Pac J Ophthalmol (Phila). 2015 Mar-Apr;4(2):121-7. doi: 10.1097/APO.0b013e3182a0af43.


Purpose: To investigate the prevalence and reconnoiter treatment modalities for Pseudoexfoliation Glaucoma (PXG) in subjects with Pseudoexfoliation Syndrome (PXF) in a rural scenario of western India.

Design: A prospective prevalence study.

Methods: Occurrence of PXG in 250 subjects with PXF was studied in the Department of Glaucoma, Shri Ganapati Netralaya, Jalna, India, from 2009 to 2011. The subject pool presented with PXF, having intraocular pressure (IOP) ≥ 20 mm of Hg, and evidencing optic nerve damage and abnormal visual fields were judiciously selected as PXG cohorts. A decision table is formulated to assist the physician in rendering medical or surgical treatment options.

Results: The prevalence of PXG increased with increasing age at 30% (95% CI: 28.56-33.72) in the 60-year-old and older population. It was predominantly higher in cohorts involved in outdoor physical activities at 46% (95% CI: 41.24-52.38). The eminence and prevalence of nuclear cataract in subjects with PXG was 72 % (95% CI: 65.72-76.34). Visual impairment was highly prevalent in 75% (95% CI: 73.43-78.29) and 10% (95% CI: 6.87-13.21) cohorts with PXG and PXF respectively. In general, linear modelling IOP was 26.37±1.64 in subjects with PXG, which was managed to 16.50±1.32 after rendering our adapted treatment protocols.

Conclusions: Increased IOP, occludable angles, and glaucomatous optic neuropathy occur more frequently in the population with PXF. It is inferred that that treatment protocol of combined cataract and glaucoma surgery gives maximum reduction in IOP.

MeSH terms

  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Antihypertensive Agents / therapeutic use
  • Cataract Extraction / statistics & numerical data
  • Exfoliation Syndrome / epidemiology*
  • Exfoliation Syndrome / physiopathology
  • Exfoliation Syndrome / therapy
  • Female
  • Glaucoma / epidemiology*
  • Glaucoma / physiopathology
  • Glaucoma / therapy
  • Humans
  • India / epidemiology
  • Intraocular Pressure / physiology
  • Male
  • Middle Aged
  • Prevalence
  • Prospective Studies
  • Vision Disorders / epidemiology
  • Vision Disorders / etiology
  • Visual Acuity / physiology
  • Visual Fields / physiology


  • Antihypertensive Agents