C-reactive protein in children with malaria in Luanda, Angola: a prospective study

Trans R Soc Trop Med Hyg. 2015 Aug;109(8):535-7. doi: 10.1093/trstmh/trv046. Epub 2015 Jun 11.


Background: C-reactive protein (CRP) is an acute phase reactant of which little is known in malaria, especially in central Africa.

Methods: In this prospective study CRP was measured in children with suspected malaria.

Results: Of 346 children, 234 had positive and 112 negative malaria microscopy. Their median CRP was 140 mg/L (IQR 88) vs 69 mg/L (IQR 129; p<0.001) respectively. CRP was positively correlated with parasitemia (p<0.001), and length of hospital stay (p=0.01), and negatively with thrombocyte count (p=0.01), and hemoglobin level (p=0.01).

Conclusion: C-reactive protein increases in malaria and correlates with parasitemia and some manifestations of complicated disease.

Keywords: C-reactive protein; Child; Developing country; Luanda; Malaria.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angola / epidemiology
  • Biomarkers / metabolism
  • C-Reactive Protein / metabolism*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Malaria / blood*
  • Malaria / epidemiology
  • Male
  • Microscopy
  • Parasitemia
  • Predictive Value of Tests
  • Prospective Studies


  • Biomarkers
  • C-Reactive Protein