Levetiracetam-induced severe acute granulomatous interstitial nephritis

Clin Kidney J. 2012 Jun;5(3):234-6. doi: 10.1093/ckj/sfs023. Epub 2012 Mar 29.


Granulomatous interstitial nephritis (GIN) is an uncommon cause of renal failure, which may be caused by drugs. Levetiracetam is an increasingly used anti-epileptic medication that is not known to cause renal toxicity in adults. To our knowledge, levetiracetam has not previously been reported as a cause of GIN. We report the case of a 69-year-old woman who developed haemodialysis-requiring acute renal failure after commencement of treatment with levetiracetam, which was shown to be GIN by renal biopsy. She made a complete recovery with cessation of levetiracetam and treatment with steroids.

Keywords: acute renal failure; granulomatous interstitial nephritis; levetiracetam.

Publication types

  • Case Reports