Small intestinal bacterial overgrowth prevalence in celiac disease patients is similar in healthy subjects and lower in irritable bowel syndrome patients

Rev Gastroenterol Mex. Apr-Jun 2015;80(2):171-4. doi: 10.1016/j.rgmx.2015.04.002. Epub 2015 Jun 10.
[Article in En, Spanish]

Abstract

Background: Untreated celiac disease has traditionally been linked to a greater risk for small intestinal bacterial overgrowth, but the existing evidence is inconclusive.

Aims: To compare the prevalence of small intestinal bacterial overgrowth in subjects with celiac disease compared with control subjects and patients with irritable bowel syndrome.

Material and methods: The study included 15 untreated celiac disease patients, 15 subjects with irritable bowel syndrome, and 15 healthy controls. All enrolled patients underwent a lactulose breath test measuring hydrogen and methane. Small intestinal bacterial overgrowth was defined according to previously published criteria.

Results: No differences were found in relation to age or sex. The prevalence of small intestinal bacterial overgrowth was similar between the celiac disease patients and the controls (20 vs. 13.33%, P=NS), whereas it was higher in patients with irritable bowel syndrome (66.66%, P<05).

Conclusion: There was no difference in the prevalence of small intestinal bacterial overgrowth between the untreated celiac disease patients and healthy controls.

Keywords: Celiac disease; Enfermedad celíaca; Irritable bowel syndrome; Small intestinal bacterial overgrowth; Sobrecrecimiento bacteriano; Síndrome de intestino irritable.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bacterial Infections / diagnosis
  • Bacterial Infections / epidemiology
  • Bacterial Infections / etiology*
  • Breath Tests
  • Case-Control Studies
  • Celiac Disease / complications
  • Celiac Disease / microbiology*
  • Female
  • Humans
  • Intestine, Small / microbiology*
  • Irritable Bowel Syndrome / complications
  • Irritable Bowel Syndrome / microbiology*
  • Male
  • Middle Aged
  • Prevalence