Renal involvement in primary Sjögren's syndrome

Rheumatology (Oxford). 2015 Sep;54(9):1541-8. doi: 10.1093/rheumatology/kev223. Epub 2015 Jun 11.


SS is a prevalent and underdiagnosed systemic disease that primarily affects epithelial tissue. It may affect renal function either as epithelial disease causing tubulointerstitial nephritis or as an immune complex-mediated glomerulopathy. These lesions may cause a variety of clinical features, both overt and occult. The epithelial disease is mediated by B and T cells, notably the Th17 subtype. We review the prevalence of renal SS, its presentation, likely pathogenesis and treatment.

Keywords: B cells; Fanconi syndrome; Sjögren’s syndrome; Th17 cells; autoantibodies; autoimmune epithelialitis; distal renal tubular acidosis; hypocomplementaemia; tubulointerstitial nephritis; vasculitis.

Publication types

  • Review

MeSH terms

  • Epithelium / physiopathology
  • Humans
  • Kidney / physiopathology
  • Kidney Diseases / epidemiology*
  • Kidney Diseases / etiology*
  • Kidney Diseases / physiopathology
  • Prevalence
  • Risk Factors
  • Sjogren's Syndrome / complications*