Spontaneous hyphaema secondary to bleeding from an iris vascular tuft in a patient with a supratherapeutic International normalised ratio: case report

BMC Ophthalmol. 2015 Jun 14:15:60. doi: 10.1186/s12886-015-0050-y.

Abstract

Background: Iris vascular tufts are rare iris stromal vascular hamartomas. Patients with iris vascular tufts generally remain asymptomatic until presenting with a spontaneous hyphaema or with mild intraoperative pupil margin haemorrhage during anterior segment surgery. This is the first reported case of spontaneous hyphaema from iris vascular tuft related to a documented supratherapeutic International Normalised Ratio as a predisposing factor. At 86 years of age, this patient also represents the oldest documented first occurrence of bleeding from an iris vascular tuft.

Case presentation: An 86 year old Caucasian lady presented with sudden and persisting loss of vision in her right eye, ocular pain and vomiting. She had a supratherapeutic International Normalised Ratio of 3.9 related to Warfarin use. Her intraocular pressure in the right eye was raised at 55 mmHg, with a 1.6 mm hyphaema and multiple iris vascular tufts visible around the entire pupil.

Conclusion: The present case highlights the risk of anticoagulation therapy as a predisposing factor for spontaneous hyphaema and adds to the management considerations for this condition. It also demonstrates the need for Ophthalmologists to be aware of iris vascular tufts as a cause for spontaneous hyphaema, independent of age and systemic associations.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Anticoagulants / therapeutic use
  • Antihypertensive Agents / administration & dosage
  • Atropine / administration & dosage
  • Eye Hemorrhage / complications*
  • Female
  • Glucocorticoids / administration & dosage
  • Hamartoma / complications*
  • Humans
  • Hyphema / diagnosis
  • Hyphema / drug therapy
  • Hyphema / etiology*
  • International Normalized Ratio*
  • Iris Diseases / complications*
  • Mydriatics / administration & dosage
  • Ophthalmic Solutions / administration & dosage
  • Prednisolone / administration & dosage
  • Prednisolone / analogs & derivatives
  • Pulmonary Embolism / drug therapy
  • Warfarin / therapeutic use

Substances

  • Anticoagulants
  • Antihypertensive Agents
  • Glucocorticoids
  • Mydriatics
  • Ophthalmic Solutions
  • Warfarin
  • Atropine
  • prednisolone acetate
  • Prednisolone