Regulation and function of the human HSP90AA1 gene

Gene. 2015 Oct 1;570(1):8-16. doi: 10.1016/j.gene.2015.06.018. Epub 2015 Jun 10.


Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different functions when compared to the constitutively expressed Hsp90β isoform, despite high amino acid sequence identity between the two proteins. These differences are likely due to variations in nucleotide sequence within non-coding regions, which allows for specific regulation through interaction with particular transcription factors, and to subtle changes in amino acid sequence that allow for unique post-translational modifications. This article will specifically focus on the expression, function and regulation of Hsp90α.

Keywords: Cancer; Drug target; Gene ontology; Gene promoter; Heat shock element; Heat shock protein; Interactome; Molecular chaperone; Post-translational modification; Stress response.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression
  • Gene Expression Regulation
  • HSP90 Heat-Shock Proteins / antagonists & inhibitors
  • HSP90 Heat-Shock Proteins / biosynthesis
  • HSP90 Heat-Shock Proteins / genetics*
  • Humans
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Promoter Regions, Genetic
  • Protein Interaction Maps
  • Protein Processing, Post-Translational


  • HSP90 Heat-Shock Proteins
  • HSP90AA1 protein, human