LRP4 in neuromuscular junction and bone development and diseases

doi:10.1016/j.bone.2015.05.012

Review

. 2015 Nov:80:101-108.

doi: 10.1016/j.bone.2015.05.012. Epub 2015 Jun 10.

LRP4 in neuromuscular junction and bone development and diseases

Chengyong Shen¹, Wen-Cheng Xiong¹, Lin Mei²

Affiliations

¹ Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA; Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA.
² Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA; Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA. Electronic address: lmei@gru.edu.

PMID: 26071838
DOI: 10.1016/j.bone.2015.05.012

Review

LRP4 in neuromuscular junction and bone development and diseases

Chengyong Shen et al. Bone. 2015 Nov.

. 2015 Nov:80:101-108.

doi: 10.1016/j.bone.2015.05.012. Epub 2015 Jun 10.

Authors

Chengyong Shen¹, Wen-Cheng Xiong¹, Lin Mei²

Affiliations

¹ Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA; Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA.
² Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA; Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA. Electronic address: lmei@gru.edu.

PMID: 26071838
DOI: 10.1016/j.bone.2015.05.012

Abstract

Low-density lipoprotein receptor-related protein 4 (LRP4) is a member of the low-density lipoprotein receptor (LDLR) family. Recent studies have revealed multiple functions and complex signaling mechanisms of LRP4 in different organs and tissues. LPR4 mutation or malfunction has been implicated in neurological disorders including congenital myasthenic syndrome, myasthenia gravis, and diseases of bone or kidney. This article is part of a Special Issue entitled "Muscle Bone Interactions".

Keywords: Bone; Low-density lipoprotein receptor-related protein 4; Myasthenia gravis; Neuromuscular junction.

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LRP4 in neuromuscular junction and bone development and diseases

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LRP4 in neuromuscular junction and bone development and diseases

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