Pheomelanin-coated iron oxide magnetic nanoparticles: a promising candidate for negative T2 contrast enhancement in magnetic resonance imaging

Chem Commun (Camb). 2015 Jun 30;51(56):11194-7. doi: 10.1039/c5cc02536b.

Abstract

We describe herein a novel type of monodisperse water-soluble magnetite nanoparticle coated with pheomelanin using an environmentally-friendly approach in aqueous medium. The results indicate superparamagnetic behaviour at room temperature and show improved negative contrast in T2-weighted MRI with a transverse relaxivity of 218 mM(-1) s(-1).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Contrast Media / chemistry*
  • Ferric Compounds / chemistry*
  • Magnetic Resonance Imaging*
  • Magnetite Nanoparticles / chemistry*
  • Melanins / chemistry*

Substances

  • Contrast Media
  • Ferric Compounds
  • Magnetite Nanoparticles
  • Melanins
  • pheomelanin
  • ferric oxide