Cytotoxic macrolides from a cultured marine dinoflagellate of the genus Amphidinium

J Kobayashi; M Ishibashi; H Nakamura; Y Ohizumi; T Yamasu; Y Hirata; T Sasaki; T Ohta; S Nozoe

doi:10.1021/np50065a021

Cytotoxic macrolides from a cultured marine dinoflagellate of the genus Amphidinium

J Nat Prod. 1989 Sep-Oct;52(5):1036-41. doi: 10.1021/np50065a021.

Authors

J Kobayashi¹, M Ishibashi, H Nakamura, Y Ohizumi, T Yamasu, Y Hirata, T Sasaki, T Ohta, S Nozoe

Affiliation

¹ Mitsubishi Kasei Institute of Life Sciences, Minamiooya, Machida, Tokyo, Japan.

PMID: 2607346
DOI: 10.1021/np50065a021

Abstract

A fourth cytotoxic macrolide, amphidinolide D[1], together with known amphidinolide B[2], has been isolated from a different batch of the cultured dinoflagellate Amphidinium sp., which was symbiotically associated with an Okinawan flatworm Amphiscolops sp. Two-dimensional nmr experiments including 1H-detected heteronuclear multiple-bond correlation (HMBC) resulted in the structure assignment of 1 and structure revision of the diene moiety (C-13-C-15) of amphidinolide B.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / isolation & purification*
Bridged Bicyclo Compounds / isolation & purification
Bridged Bicyclo Compounds / pharmacology*
Bridged Bicyclo Compounds, Heterocyclic*
Bridged-Ring Compounds / pharmacology*
Dinoflagellida / analysis*
Drug Screening Assays, Antitumor
Magnetic Resonance Spectroscopy
Molecular Structure
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Bridged Bicyclo Compounds
Bridged Bicyclo Compounds, Heterocyclic
Bridged-Ring Compounds
amphidinolide D