Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

doi:10.1016/j.cmet.2015.05.011

Review

. 2015 Jul 7;22(1):4-11.

doi: 10.1016/j.cmet.2015.05.011. Epub 2015 Jun 11.

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

P Darrell Neufer¹, Marcas M Bamman², Deborah M Muoio³, Claude Bouchard⁴, Dan M Cooper⁵, Bret H Goodpaster⁶, Frank W Booth⁷, Wendy M Kohrt⁸, Robert E Gerszten⁹, Mark P Mattson¹⁰, Russell T Hepple¹¹, William E Kraus³, Michael B Reid¹², Sue C Bodine¹³, John M Jakicic¹⁴, Jerome L Fleg¹⁵, John P Williams¹⁶, Lyndon Joseph¹⁶, Mary Evans¹⁷, Padma Maruvada¹⁷, Mary Rodgers¹⁸, Mary Roary¹⁹, Amanda T Boyce²⁰, Jonelle K Drugan²⁰, James I Koenig²¹, Richard H Ingraham²², Danuta Krotoski²³, Mary Garcia-Cazarin²⁴, Joan A McGowan²⁰, Maren R Laughlin¹⁷

Affiliations

¹ East Carolina Diabetes and Obesity Institute, Departments of Physiology and Kinesiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address: neuferp@ecu.edu.
² UAB Center for Exercise Medicine and Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
³ Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.
⁴ Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
⁵ UC Irvine Institute for Clinical and Translational Science and Department of Pediatrics, University of California, Irvine, CA 92697, USA.
⁶ Translational Research Institute for Metabolism and Diabetes, Florida Hospital - Sanford-Burnham Medical Research Institute, Orlando, FL 32804, USA.
⁷ Departments of Biomedical Sciences, Medical Pharmacology and Physiology, and Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA.
⁸ Division of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
⁹ Department of Medicine, Harvard Medical School, Boston, MA Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA.
¹⁰ Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
¹¹ Department of Kinesiology, McGill University Health Center, McGill University, Montreal, QC H2W 1S4, Canada.
¹² Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.
¹³ Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616, USA.
¹⁴ Department of Health and Physical Activity, Physical Activity and Weight Management Research Center, University of Pittsburgh, PA 15261, USA.
¹⁵ National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
¹⁶ National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
¹⁷ National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
¹⁸ National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.
¹⁹ National Institute of Nursing Research, National Institutes of Health, Bethesda, MD 20892, USA.
²⁰ National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
²¹ National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
²² Center for Scientific Review, National Institutes of Health, Bethesda, MD 20892, USA.
²³ Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
²⁴ Office of Disease Prevention, National Institutes of Health, Bethesda, MD 20892, USA.

PMID: 26073496
DOI: 10.1016/j.cmet.2015.05.011

Free article

Review

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

P Darrell Neufer et al. Cell Metab. 2015.

Free article

. 2015 Jul 7;22(1):4-11.

doi: 10.1016/j.cmet.2015.05.011. Epub 2015 Jun 11.

Authors

Affiliations

¹ East Carolina Diabetes and Obesity Institute, Departments of Physiology and Kinesiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address: neuferp@ecu.edu.
² UAB Center for Exercise Medicine and Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
³ Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.
⁴ Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
⁵ UC Irvine Institute for Clinical and Translational Science and Department of Pediatrics, University of California, Irvine, CA 92697, USA.
⁶ Translational Research Institute for Metabolism and Diabetes, Florida Hospital - Sanford-Burnham Medical Research Institute, Orlando, FL 32804, USA.
⁷ Departments of Biomedical Sciences, Medical Pharmacology and Physiology, and Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA.
⁸ Division of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
⁹ Department of Medicine, Harvard Medical School, Boston, MA Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA.
¹⁰ Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
¹¹ Department of Kinesiology, McGill University Health Center, McGill University, Montreal, QC H2W 1S4, Canada.
¹² Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.
¹³ Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616, USA.
¹⁴ Department of Health and Physical Activity, Physical Activity and Weight Management Research Center, University of Pittsburgh, PA 15261, USA.
¹⁵ National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
¹⁶ National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
¹⁷ National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
¹⁸ National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.
¹⁹ National Institute of Nursing Research, National Institutes of Health, Bethesda, MD 20892, USA.
²⁰ National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
²¹ National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
²² Center for Scientific Review, National Institutes of Health, Bethesda, MD 20892, USA.
²³ Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
²⁴ Office of Disease Prevention, National Institutes of Health, Bethesda, MD 20892, USA.

PMID: 26073496
DOI: 10.1016/j.cmet.2015.05.011

Abstract

The beneficial effects of physical activity (PA) are well documented, yet the mechanisms by which PA prevents disease and improves health outcomes are poorly understood. To identify major gaps in knowledge and potential strategies for catalyzing progress in the field, the NIH convened a workshop in late October 2014 entitled "Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits." Presentations and discussions emphasized the challenges imposed by the integrative and intermittent nature of PA, the tremendous discovery potential of applying "-omics" technologies to understand interorgan crosstalk and biological networking systems during PA, and the need to establish an infrastructure of clinical trial sites with sufficient expertise to incorporate mechanistic outcome measures into adequately sized human PA trials. Identification of the mechanisms that underlie the link between PA and improved health holds extraordinary promise for discovery of novel therapeutic targets and development of personalized exercise medicine.

PubMed Disclaimer

Cited by

Exploiting the therapeutic potential of contracting skeletal muscle-released extracellular vesicles in cancer: Current insights and future directions.
Pinto AC, Tavares P, Neves B, Oliveira PF, Vitorino R, Moreira-Gonçalves D, Ferreira R. Pinto AC, et al. J Mol Med (Berl). 2024 Mar 7. doi: 10.1007/s00109-024-02427-7. Online ahead of print. J Mol Med (Berl). 2024. PMID: 38451309 Review.
Exercise potentially prevents colorectal cancer liver metastases by suppressing tumor epithelial cell stemness via RPS4X downregulation.
Wan R, Chen Y, Feng X, Luo Z, Peng Z, Qi B, Qin H, Lin J, Chen S, Xu L, Tang J, Zhang T. Wan R, et al. Heliyon. 2024 Feb 24;10(5):e26604. doi: 10.1016/j.heliyon.2024.e26604. eCollection 2024 Mar 15. Heliyon. 2024. PMID: 38439884 Free PMC article.
Chronic exercise improves hepatic acylcarnitine handling.
Hernández-Saavedra D, Hinkley JM, Baer LA, Pinckard KM, Vidal P, Nirengi S, Brennan AM, Chen EY, Narain NR, Bussberg V, Tolstikov VV, Kiebish MA, Markunas C, Ilkayeva O, Goodpaster BH, Newgard CB, Goodyear LJ, Coen PM, Stanford KI. Hernández-Saavedra D, et al. iScience. 2024 Feb 1;27(3):109083. doi: 10.1016/j.isci.2024.109083. eCollection 2024 Mar 15. iScience. 2024. PMID: 38361627 Free PMC article.
Effect of histamine-receptor antagonism on the circulating inflammatory cell and cytokine response to exercise: A pilot study.
Ely MR, Mangum JE, Needham KW, Minson CT, Halliwill JR. Ely MR, et al. Physiol Rep. 2024 Feb;12(3):e15936. doi: 10.14814/phy2.15936. Physiol Rep. 2024. PMID: 38307711 Free PMC article. Clinical Trial.
A 6-month exercise intervention clinical trial in women: effects of physical activity on multi-omics biomarkers and health during the first wave of COVID-19 in Korea.
Park J, Kim J, Kang J, Choi J, Kim JE, Min KJ, Choi SW, Cho JY, Lee M, Choi JY. Park J, et al. BMC Sports Sci Med Rehabil. 2024 Jan 29;16(1):30. doi: 10.1186/s13102-024-00824-6. BMC Sports Sci Med Rehabil. 2024. PMID: 38287431 Free PMC article.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

Affiliations

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources