Cross-Presentation in Mouse and Human Dendritic Cells

Adv Immunol. 2015:127:1-31. doi: 10.1016/ Epub 2015 Apr 8.


Cross-presentation designates the presentation of exogenous antigens on major histocompatibility complex class I molecules and is essential for the initiation of cytotoxic immune responses. It is now well established that dendritic cells (DCs) are the best cross-presenting cells. In this chapter, we will discuss recent advances in our understanding of the molecular mechanisms of cross-presentation. We will also describe the different DC subsets identified in mouse and human, and their functional specialization for cross-presentation. Finally, we will summarize the current knowledge of the role of cross-presentation in pathological situations.

Keywords: Cross-presentation; DC subsets; Dendritic cells; Human; Phagosome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Autoimmunity*
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology*
  • Endocytosis
  • Histocompatibility Antigens Class I / immunology
  • Humans
  • Mice
  • Neoplasms / immunology*
  • Virus Diseases / immunology*


  • Histocompatibility Antigens Class I