Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila

Neuron. 2015 Jul 1;87(1):139-51. doi: 10.1016/j.neuron.2015.05.032. Epub 2015 Jun 11.


Animals can detect and consume nutritive sugars without the influence of taste. However, the identity of the taste-independent nutrient sensor and the mechanism by which animals respond to the nutritional value of sugar are unclear. Here, we report that six neurosecretory cells in the Drosophila brain that produce Diuretic hormone 44 (Dh44), a homolog of the mammalian corticotropin-releasing hormone (CRH), were specifically activated by nutritive sugars. Flies in which the activity of these neurons or the expression of Dh44 was disrupted failed to select nutritive sugars. Manipulation of the function of Dh44 receptors had a similar effect. Notably, artificial activation of Dh44 receptor-1 neurons resulted in proboscis extensions and frequent episodes of excretion. Conversely, reduced Dh44 activity led to decreased excretion. Together, these actions facilitate ingestion and digestion of nutritive foods. We propose that the Dh44 system directs the detection and consumption of nutritive sugars through a positive feedback loop.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / metabolism*
  • Drosophila
  • Drosophila Proteins / drug effects
  • Drosophila Proteins / metabolism*
  • Feedback, Sensory
  • Feeding Behavior / physiology*
  • Fructose / pharmacology
  • Glucose / pharmacology
  • Insect Hormones / metabolism*
  • Neurons / metabolism*
  • Neurosecretion / drug effects
  • Nutritive Sweeteners / metabolism*
  • Nutritive Sweeteners / pharmacology
  • Receptors, Cell Surface / drug effects
  • Receptors, Cell Surface / metabolism
  • Trehalose / pharmacology


  • Dh44 protein, Drosophila
  • Drosophila Proteins
  • Insect Hormones
  • Nutritive Sweeteners
  • Receptors, Cell Surface
  • diuretic hormone 44 receptor 1, Drosophila
  • diuretic hormone 44 receptor 2, Drosophila
  • Fructose
  • Trehalose
  • Glucose