Diffusion kurtosis imaging of the pancreas for the assessment of HbA1c levels

Yoshifumi Noda; Masayuki Kanematsu; Satoshi Goshima; Yukio Horikawa; Jun Takeda; Hiroshi Kondo; Haruo Watanabe; Hiroshi Kawada; Nobuyuki Kawai; Yukichi Tanahashi; Kyongtae T Bae

doi:10.1002/jmri.24982

Diffusion kurtosis imaging of the pancreas for the assessment of HbA1c levels

J Magn Reson Imaging. 2016 Jan;43(1):159-65. doi: 10.1002/jmri.24982. Epub 2015 Jun 12.

Authors

Affiliations

¹ Department of Radiology, Gifu University Hospital, Gifu, Japan.
² Department of Radiology Services, Gifu University Hospital, Gifu, Japan.
³ Department of Diabetes and Endocrinology, Gifu University Hospital, Gifu, Japan.
⁴ Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

PMID: 26074129
DOI: 10.1002/jmri.24982

Abstract

Purpose: To evaluate the feasibility of diffusion kurtosis (DK) imaging of the pancreas for the assessment of hemoglobin (Hb) A1c values.

Materials and methods: Our Institutional Review Board approved this prospective study and written informed consent was obtained. In all, 102 consecutive patients with suspected pancreatic disease underwent magnetic resonance imaging (MRI), including DK imaging. Patients were classified into three groups according to American Diabetes Association criteria: HbA1c < 5.7% (group 1), 5.7% ≤ HbA1c < 6.5% (group 2), and HbA1c ≥ 6.5% (group 3). Mean kurtosis (MK) and apparent diffusion coefficient (ADC) of pancreatic parenchyma were computed. MRI measurements and HbA1c values were then compared.

Results: HbA1c values positively correlated with MK (r = 0.66, P < 0.0001). Group 3 was significantly (P < 0.05) higher (P < 0.05) in MK than groups 1 and 2. The sensitivity, specificity, and area under the ROC curve of the MK for the detection of group 3 were 90%, 88%, and 0.92, respectively.

Conclusion: The MK measurement on DK imaging of the pancreas could be a potential biomarker for assessing HbA1c level.

Keywords: diffusion kurtosis imaging; hemoglobin A1c; magnetic resonance imaging; pancreas.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers / analysis
Diabetes Mellitus / diagnosis*
Diabetes Mellitus / metabolism*
Diffusion Magnetic Resonance Imaging / methods*
Feasibility Studies
Female
Glycated Hemoglobin / analysis*
Humans
Image Interpretation, Computer-Assisted / methods*
Male
Middle Aged
Molecular Imaging / methods
Pancreas / metabolism*
Pancreas / pathology
Reproducibility of Results
Sensitivity and Specificity
Young Adult

Substances

Biomarkers
Glycated Hemoglobin A
hemoglobin A1c protein, human