Wound healing. Oral and topical activity of Aloe vera

J Am Podiatr Med Assoc. 1989 Nov;79(11):559-62. doi: 10.7547/87507315-79-11-559.


The influence of Aloe vera, orally and topically, on wound healing was studied. Wounds were induced on both sides of the vertebral column of ICR mice using a biopsy punch. For the oral study, experimental animals received A. vera in their drinking water for 2 months, whereas the control animals received only water. In the topical study, experimental animals were given 25% A. vera in Eucerin cream topically. The control animals received cream only. A 62.5% reduction in wound diameter was noted in mice receiving 100 mg/kg/day oral A. vera and a 50.8% reduction was recorded in animals receiving topical 25% A. vera. These data suggest that A. vera is effective by both oral and topical routes of administration.

MeSH terms

  • Administration, Oral
  • Administration, Topical
  • Aloe*
  • Animals
  • Male
  • Mice
  • Mice, Inbred ICR
  • Plants, Medicinal*
  • Wound Healing / drug effects*
  • Wounds and Injuries / drug therapy*
  • Wounds and Injuries / pathology