Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

Malgorzata Szczepańska; Adrianna Mostowska; Przemyslaw Wirstlein; Jana Skrzypczak; Paweł P Jagodziłski

doi:10.3892/br.2014.409

Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

Biomed Rep. 2015 Mar;3(2):220-224. doi: 10.3892/br.2014.409. Epub 2014 Dec 19.

Authors

Malgorzata Szczepańska¹, Adrianna Mostowska², Przemyslaw Wirstlein³, Jana Skrzypczak¹, Paweł P Jagodziłski²

Affiliations

¹ Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznań 60-781, Poland.
² Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznań 60-781, Poland.
³ Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznań 60-781, Poland ; Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznań 60-781, Poland.

Abstract

There are inconsistent data on the contribution of vascular endothelial growth factor (VEGF) -460 C/T (rs833061), +405 G/C (rs2010963) and +936 C/T (rs3025039) single-nucleotide polymorphisms (SNPs) to endometriosis in different ethnicities. Therefore, using high-resolution melting curve analysis, the present study examined the distribution of these SNPs in females with endometriosis-related infertility and a control group. None of the three VEGF SNPs were associated with endometriosis-related infertility in the dominant and recessive models. The lowest P-values of the trend were observed for the VEGF +936 C/T (rs3025039) SNP in endometriosis-related infertility (P_trend =0.149). Similarly, haplotype analyses of VEGF SNPs did not demonstrate any SNP combination as a risk for endometriosis-related infertility, and the lowest overall P-values, P=0.141 and P_corr =0.395, were observed for a haplotype (TGT) of the above SNPs. Taken together, these results did not demonstrate the contribution of VEGF C/T, +405 G/C and +936 C/T SNPs to endometriosis-related infertility.

Keywords: endometriosis; infertility; polymorphisms; vascular endothelial growth factor.