Characteristics of Non-Opioid Substance Misusers Among Patients Enrolling in Opioid Treatment Programs: A Latent Class Analysis

J Addict Dis. 2015;34(2-3):141-50. doi: 10.1080/10550887.2015.1059226.


Using latent class analysis, this study examined the pattern of non-opioid substance misuse among 19,101 enrollees into 85 opioid treatment programs. The most frequent non-opioid drugs were cannabis, anti-anxiety medications, and cocaine. Four non-opioid drug use latent classes were identified: low-use (73%), prescription drug use (16%), marijuana and cocaine use (8.5%), and poly-drug use (2.5%). Compared to the low-use class, participants in the other classes were more likely to be female, Caucasian, use tobacco, have chronic pain, and use prescription opioids either with or without heroin. Recognition of characteristics derived from these classes can improve opioid treatment program services.

Keywords: Opioids; latent class analysis; prescription drugs; substance use disorder; substance use treatment.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Male
  • Opioid-Related Disorders / rehabilitation
  • Risk Factors
  • Substance Abuse Treatment Centers / statistics & numerical data
  • Substance-Related Disorders / epidemiology*
  • United States / epidemiology
  • Young Adult