Primary rhabdoid tumor of the ovary: When large cells become small cells

Alex Rabinovich; Leora Witkowski; Ruthy Shaco-Levi; Mihai Meirovitz; Martin Hasselblatt; William D Foulkes

doi:10.1016/j.gore.2015.03.005

Primary rhabdoid tumor of the ovary: When large cells become small cells

Gynecol Oncol Rep. 2015 Mar 19:12:64-6. doi: 10.1016/j.gore.2015.03.005. eCollection 2015 Apr.

Authors

Alex Rabinovich¹, Leora Witkowski², Ruthy Shaco-Levi³, Mihai Meirovitz¹, Martin Hasselblatt⁴, William D Foulkes²

Affiliations

¹ Division of Gynecologic Oncology, Ben-Gurion University of the Negev, Beer-Sheva, Israel ; Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
² Department of Medical Genetics, Lady Davis Institute and Segal Cancer Centre, Jewish General Hospital, McGill University, Montreal, QC, Canada ; Department of Human Genetics, McGill University, Montreal, QC, Canada ; Department of Medical Genetics, Research Institute, McGill University Health Centre, Montreal, QC, Canada.
³ Department of Pathology, Ben-Gurion University of the Negev, Beer-Sheva, Israel ; Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
⁴ Institute of Neuropathology, University Hospital-Munster, Germany.

Abstract

•The third case of pure primary malignant rhabdoid tumor of the ovary (MRTO) is described•SMARCA4 and SMARCB1 genetic analysis and immunohistochemistry are necessary for correct diagnosis of MRTO•MRTO and small cell carcinoma of the ovary, hypercalcemic type are essentially the same and should be treated as such.

Keywords: Genetic testing; Ovary; Rhabdoid; SMARCA4; Sequencing; Tumor.

Publication types

Case Reports