The Relationship Among Perceived Stress, Symptoms, and Inflammation in Persons With Inflammatory Bowel Disease

Am J Gastroenterol. 2015 Jul;110(7):1001-12; quiz 1013. doi: 10.1038/ajg.2015.147. Epub 2015 Jun 16.


Objectives: Previous studies have demonstrated that stress is associated with increased disease activity in individuals with inflammatory bowel disease (IBD). The association between perceived stress and gastrointestinal inflammation is not well described.

Methods: Participants were recruited from a population-based registry of individuals with known IBD. Symptomatic disease activity was assessed using validated clinical indices: the Manitoba IBD Index (MIBDI) and Harvey Bradshaw Index (HBI) for Crohn's disease (CD), and Powell Tuck Index (PTI) for ulcerative colitis (UC). Perceived stress was measured using Cohen's Perceived Stress Scale (CPSS). Intestinal inflammation was determined through measurement of fecal calprotectin (FCAL), with a level exceeding 250 μg/g indicating significant inflammation. Logistic regressions were used to evaluate the association between intestinal inflammation, perceived stress, and disease activity.

Results: Of the 478 participants with completed surveys and stool samples, perceived stress was associated with symptomatic activity (MIBDI) for both CD and UC (1.07 per 1-point increase on the CPSS, 95% confidence interval (CI) 1.03-1.10 and 1.03-1.11, respectively). There was no significant association between perceived stress and intestinal inflammation for either CD or UC. Active symptoms (MIBDI ≤3) were associated with intestinal inflammation in UC (odds ratio (OR) 3.94, 95% CI 1.65-9.43), but not in CD (OR 0.98, 95% CI 0.51-1.88).

Conclusions: Symptomatic disease activity was unrelated to intestinal inflammation in CD and only weakly associated in UC. Although there was a strong relationship between perceived stress and gastrointestinal symptoms, perceived stress was unrelated to concurrent intestinal inflammation. Longitudinal investigation is required to determine the directionality of the relationship between perceived stress, inflammation, and symptoms in IBD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Colitis, Ulcerative / psychology
  • Crohn Disease / psychology
  • Cross-Sectional Studies
  • Feces / chemistry
  • Female
  • Humans
  • Inflammation
  • Inflammatory Bowel Diseases / diagnosis
  • Inflammatory Bowel Diseases / metabolism
  • Inflammatory Bowel Diseases / psychology*
  • Leukocyte L1 Antigen Complex / metabolism*
  • Logistic Models
  • Male
  • Manitoba / epidemiology
  • Middle Aged
  • Registries
  • Self Report
  • Severity of Illness Index
  • Social Perception*
  • Stress, Psychological / complications*
  • Surveys and Questionnaires


  • Leukocyte L1 Antigen Complex