An ecosystem of cancer cell line factories to support a cancer dependency map

doi:10.1038/nrg3967

. 2015 Jul;16(7):373-4.

doi: 10.1038/nrg3967. Epub 2015 Jun 16.

An ecosystem of cancer cell line factories to support a cancer dependency map

Jesse S Boehm¹, Todd R Golub²

Affiliations

¹ Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
² 1] Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA. [2] Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA. [3] Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, USA. [4] Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, Maryland 20815, USA.

PMID: 26077369
DOI: 10.1038/nrg3967

An ecosystem of cancer cell line factories to support a cancer dependency map

Jesse S Boehm et al. Nat Rev Genet. 2015 Jul.

. 2015 Jul;16(7):373-4.

doi: 10.1038/nrg3967. Epub 2015 Jun 16.

Authors

Jesse S Boehm¹, Todd R Golub²

Affiliations

¹ Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
² 1] Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA. [2] Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA. [3] Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, USA. [4] Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, Maryland 20815, USA.

PMID: 26077369
DOI: 10.1038/nrg3967

Abstract

Jesse Boehm and Todd Golub call for an international effort to establish >10,000 cancer cell line models as a community resource. Cancer cell line factories will facilitate the creation of a cancer dependency map, connecting cancer genomics to therapeutic dependencies.

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References

1. Cell. 2015 May 7;161(4):933-45 - PubMed
1. Nature. 2014 Jan 23;505(7484):495-501 - PubMed
1. Nature. 2012 Mar 28;483(7391):570-5 - PubMed
1. Nature. 2012 Mar 28;483(7391):603-7 - PubMed
1. Am J Pathol. 2012 Feb;180(2):599-607 - PubMed

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[1] Cell. 2015 May 7;161(4):933-45 - PubMed

[2] Cell. 2015 May 7;161(4):933-45 - PubMed

[3] Nature. 2014 Jan 23;505(7484):495-501 - PubMed

[4] Nature. 2014 Jan 23;505(7484):495-501 - PubMed

[5] Nature. 2012 Mar 28;483(7391):570-5 - PubMed

[6] Nature. 2012 Mar 28;483(7391):570-5 - PubMed

[7] Nature. 2012 Mar 28;483(7391):603-7 - PubMed

[8] Nature. 2012 Mar 28;483(7391):603-7 - PubMed

[9] Am J Pathol. 2012 Feb;180(2):599-607 - PubMed

[10] Am J Pathol. 2012 Feb;180(2):599-607 - PubMed

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An ecosystem of cancer cell line factories to support a cancer dependency map

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An ecosystem of cancer cell line factories to support a cancer dependency map

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