Exclusive enteral nutrition in children with Crohn's disease

World J Gastroenterol. 2015 Jun 14;21(22):6809-16. doi: 10.3748/wjg.v21.i22.6809.


Exclusive enteral nutrition involves the use of a complete liquid diet, with the exclusion of normal dietary components for a defined period of time, as a therapeutic measure to induce remission in active Crohn's disease (CD). This very efficacious approach leads to high rates of remission, especially in children and adolescents newly diagnosed with CD. This intervention also results in mucosal healing, nutritional improvements and enhanced bone health. Whilst several recent studies have provided further elaboration of the roles of exclusive enteral nutrition in the management of CD, other reports have provided new understanding of the mechanisms by which this intervention acts.

Keywords: Children; Crohn’s disease; Exclusive enteral nutrition; Mechanisms; Nutrition; Outcomes.

Publication types

  • Editorial
  • Review

MeSH terms

  • Adolescent
  • Animals
  • Child
  • Child Nutritional Physiological Phenomena
  • Crohn Disease / diagnosis
  • Crohn Disease / physiopathology
  • Crohn Disease / therapy*
  • Enteral Nutrition* / adverse effects
  • Health Status
  • Humans
  • Intestinal Mucosa / pathology
  • Intestinal Mucosa / physiopathology
  • Nutrition Assessment
  • Nutritional Status
  • Remission Induction
  • Treatment Outcome
  • Wound Healing

Supplementary concepts

  • Pediatric Crohn's disease