The effects of normal aging on amyloid-β deposition in nondemented adults with Down syndrome as imaged by carbon 11-labeled Pittsburgh compound B

Alzheimers Dement. 2016 Apr;12(4):380-90. doi: 10.1016/j.jalz.2015.05.013. Epub 2015 Jun 13.


Introduction: In Down syndrome (DS), the overproduction of amyloid precursor protein is hypothesized to predispose young adults to early expression of Alzheimer-like neuropathology.

Methods: PET imaging with carbon 11-labeled Pittsburgh compound B examined the pattern of amyloid-β deposition in 68 nondemented adults with DS (30-53 years) to determine the relationship between deposition and normal aging. Standard uptake value ratio (SUVR) images were created with cerebellar gray matter as the reference region.

Results: Multiple linear regression revealed slight but highly significant (corrected P < .05) positive correlations between SUVR and age. The striatum showed the strongest correlation, followed by precuneus, parietal cortex, anterior cingulate, frontal cortex, and temporal cortex.

Conclusion: There is an age-related amyloid-β deposition in the DS population, but as a pattern of elevated cortical retention becomes apparent, the correlation of SUVR with age ceases to be significant. Factors unrelated to aging may drive an increase in deposition during early Alzheimer's disease pathogenesis.

Keywords: Aging; Alzheimer's disease; Amyloid imaging; Down syndrome; PiB.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aging / metabolism*
  • Aniline Compounds
  • Apolipoproteins E / genetics
  • Brain / diagnostic imaging*
  • Brain / metabolism*
  • Carbon Radioisotopes
  • Cohort Studies
  • Down Syndrome / diagnostic imaging*
  • Down Syndrome / genetics
  • Down Syndrome / metabolism*
  • Female
  • Humans
  • Linear Models
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Positron-Emission Tomography
  • Radiopharmaceuticals
  • Thiazoles


  • 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • Aniline Compounds
  • Apolipoproteins E
  • Carbon Radioisotopes
  • Radiopharmaceuticals
  • Thiazoles