Development of a patient-reported outcome instrument to assess complex activities of daily living and interpersonal functioning in persons with mild cognitive impairment: The qualitative research phase

Alzheimers Dement. 2016 Jan;12(1):75-84. doi: 10.1016/j.jalz.2015.04.008. Epub 2015 Jun 13.


Introduction: As drug development research efforts move toward studying patients earlier in the course of Alzheimer's disease (AD), it is important to incorporate the patient's perspective into measurement of outcomes.

Methods: This article summarizes the qualitative work of the Patient-Reported Outcome Consortium's Cognition Working Group in the development of a new self-reported outcome measure in persons with mild cognitive impairment (MCI) due to suspected AD, herein referred to as MCI.

Results: The draft measure captures the patient's voice for two functional domains, complex activities of daily living and interpersonal functioning.

Discussion: This work represents a series of initial steps in the development of this rating scale. The next steps are to conduct psychometric analysis and evaluate the role of insight.

Keywords: Activities of daily living; Alzheimer's disease; Cognition; Critical Path Institute; Interpersonal functioning; Mild cognitive impairment; Patient-reported outcome; Qualitative.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Activities of Daily Living*
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / psychology
  • Cognitive Dysfunction / psychology*
  • Female
  • Humans
  • Interpersonal Relations*
  • Male
  • Middle Aged
  • Neuropsychological Tests / standards
  • Patient Outcome Assessment*
  • Qualitative Research
  • Self Report