Nuclear envelope: positioning nuclei and organizing synapses

Curr Opin Cell Biol. 2015 Jun;34:84-93. doi: 10.1016/ Epub 2015 Jun 12.


The nuclear envelope plays an essential role in nuclear positioning within cells and tissues. This review highlights advances in understanding the mechanisms of nuclear positioning during skeletal muscle and central nervous system development. New findings, particularly about A-type lamins and Nesprin1, may link nuclear envelope integrity to synaptic integrity. Thus synaptic defects, rather than nuclear mispositioning, may underlie human pathologies associated with mutations of nuclear envelope proteins.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Cell Nucleus / metabolism
  • Humans
  • Muscle, Skeletal / metabolism
  • Nuclear Envelope / metabolism*
  • Nuclear Proteins / metabolism
  • Synapses / metabolism*


  • Nuclear Proteins