Clinical use of photodynamic therapy in ocular tumors

Surv Ophthalmol. 2015 Nov-Dec;60(6):557-74. doi: 10.1016/j.survophthal.2015.05.004. Epub 2015 Jun 12.


Although the introduction of intravitreal anti-vascular endothelial growth factor drugs reduced the indications for photodynamic therapy in ophthalmology, it may still be used in various ocular tumors. Although many studies have shown that photodynamic therapy is effective in ocular tumors, the literature consists of case reports and series. In this review, we systematically performed a meta-analysis for the use of photodynamic therapy in circumscribed choroidal hemangioma, diffuse choroidal hemangioma, retinal capillary hemangioma, von Hippel-Lindau angiomatosis, choroidal melanoma, retinal astrocytoma, retinoblastoma, eyelid tumors, conjunctival tumors, and choroidal metastasis.

Keywords: choroidal hemangioma; choroidal melanoma; eyelid tumors; ocular tumors; photodynamic therapy; retinal astrocytoma; retinal capillary hemangioma; retinoblastoma.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Astrocytoma / drug therapy
  • Choroid Neoplasms / drug therapy
  • Conjunctival Neoplasms / drug therapy
  • Eye Neoplasms / drug therapy*
  • Eyelid Neoplasms / drug therapy
  • Hemangioma / drug therapy
  • Hemangioma, Capillary / drug therapy
  • Humans
  • Melanoma / drug therapy
  • Photochemotherapy*
  • Photosensitizing Agents / therapeutic use*
  • Retinal Neoplasms / drug therapy
  • Retinoblastoma / drug therapy


  • Photosensitizing Agents